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Many common health conditions can lead to erectile dysfunction, including diabetes, cardiovascular disease, low testosterone, obesity, and depression. Untreated, these conditions can interfere with your body’s ability to sustain an erection, even when using medications like tadalafil. Cialis works by increasing blood flow to the penis during arousal, making it easier to get an erection.

Cialis, along with the other commonly used ED tablets are usually effective and well tolerated medication. However, men taking some prescription medicines, most notably drugs called nitrates used to treat heart disease, but also some other prescription medicines, should not take Cialis. Men who have some medical conditions, particularly those affecting exercise tolerance should also not take Cialis. Always consult your regular doctor before starting erectile dysfunction medication. Online doctors carry out checks through online questionnaires, but this does not replace initial face-to-face assessments and regular medical check-ups are necessary. Affordable and Effective Tadalafil 20mg TabletsTadalafil 20mg tablets offer a cost-effective alternative to the branded erectile dysfunction medication Cialis, providing effective treatment for ED.

This signal cascade is attenuated by PDE5 which breaks the phosphodiester bond of cGMP, converting it to GMP. Inhibition of PDE5 by tadalafil increases signaling via the PKG cascade which supports penile smooth muscle relaxation during sexual arousal by decreasing Ca2+ entry into smooth muscle cells. This smooth muscle relaxation allows blood to fill the corpus cavernosum thereby producing an erection.

The tablet should be taken with water half an hour prior to sexual intercourse and should not be taken more than once within 24 hours. Tadalafil will only work with sexual stimulation&nbsp